Biomechanical phenomena in living systems present exciting puzzles from both scientific and engineering perspectives. For instance, functional responses such as brain signaling, metabolic changes, wound healing, and drug delivery, along with the architectural design in living systems raise numerous fundamental "why, how, and when" questions that remain unexplored across various length and time scales. Driven by this curiosity, our faculty investigates the underlying mechanistic principles that govern the functionality and structural integrity of living systems, with the aim of developing transformative technologies to improve human health and the environment. Using theoretical, computational, and experimental techniques, current research areas being explored by our faculty include foundational concepts behind digital-twins of human physiology in health and disease, neuronal signaling, organelle dynamics, cellular transport, next-generation molecular diagnostic tools, wearable and point-of-care sensors, AI-enhanced biosensing technologies, novel bio-nanocomposites development, bio-inspired designs, personalized drug delivery, estimation and control of biophysical systems, and sustainable manufacturing techniques for biomedical, structural, food, water, textiles, energy, and environmental applications.